Every so often you come across a paper with chemistry so awesome you get pulled in like a good novel. But even rarer still are the papers with incredibly complete “experimental” sections. I’m talking complete NMR data on every compound. Melting points. Conditions for HPLC, like retention times, injection volumes, exact column specifications, and even flow rates. But this paper in OPRD by Lipton et al may take the cake for best experimental I’ve ever seen.
Now admittedly, I don’t often read any of the process development journals. Maybe this level of attention to detail is commonplace in process development research; I can say it’s generally not in more traditional synthesis journals. In this case, the authors not only described in complete detail each and every synthesis, but they even saw it fit to include, well, a table like this for each compound:
This kinda work really warms the cockles of my heart. Because this is generally stuff you’d do anyway in the course of synthesis research, the authors just wrote it all down.